Rafael Benitez and Liverpool travel to the Estádio da Luz to take on a formidable Benfica side in the last eight of the Europa League.
Benitez has called for his "big names" to set an example as the Reds look to win the only piece of silverware they are able to this season.
Benfica vs Liverpool Preview
Meanwhile, Roy Hodgson will try to keep the European dream alive as he attempts to guide his side into yet more unchartered territory.
Having slayed Juventus and Shakhtar Donetsk in this competition, the Cottagers will look to eliminate German giant Wolfburg in the quarter-finals.
Fulham vs Wolfsburg Preview
An all-Spanish affair is also set to illuminate the elite eight of the Europa League, as Valencia take on La Liga rivals Atletico Madrid.
League form would make Valencia favourites for a tie they begin on home soil on Thursday, but this is likely to mean much more to Atletico Madrid as Los Che focus their efforts on securing Champions League football for next season.
Valencia vs Atletico Madrid Preview
Finally, Hamburg take on Standard Liege, with Ruud van Nistelrooy bent on winning his first European title of his career with the German outift this season.
Hamburg vs Standard Liege Preview
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